WEILL
CORNELL MEDICAL COLLEGE RESEARCHERS
MAKE BLIND
MOUSE RETINAS SEE.
Two researchers at Weill
Cornell Medical College have deciphered a mouse's retina's neural code and
coupled this information to a novel prosthetic device to restore sight to blind
mice. Furthermore, the researchers say they've also cracked the code for a
monkey brain, which is essentially identical to that of a human. They hope to
quickly design and test a device that blind humans can use. While current
prosthetics provide blind users with spots and edges of light to help them
navigate, this novel device provides the code to restore normal vision. The
code is so accurate that it can allow facial features to be discerned and allow
animals to track moving images. The researchers' work was reported in the
Proceedings of the National Academy of Sciences. According to lead researcher
Dr. Sheila Nirenberg, “Not only is it necessary to stimulate large numbers of
cells, but they also have to be stimulated with the right code–the code the
retina normally uses to communicate with the brain.” She says that the findings
of the recent research show that the critical ingredients for building a highly
effective retinal prosthetic–the retina's code and a high resolution
stimulating method–are now, to a large extent, in place and that her retinal
prosthetic will need to undergo human clinical trials, especially to test
safety of the gene therapy component, which delivers the light–sensitive
protein.
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